Does iodinated contrast medium amplify DNA damage during exposure to radiation

Effect of Exposure to Ionizing Radiation on Biomarker of Oxidative Damage of DNA

Introduction: one of the most important complications of exposure to ionizing radiation is emergence of cancer tumors, which happens as a result of oxidative DNA.  Therefore, the present study was conducted, aimed to measuring 8-DIHYDROxy- 2’- DEOXYGUANOSINE (8-OHdG) level in radiographers’ urine as oxidative damage biomarker, as well as comparing this biomarker with cumulative effective doses....

Radiation track and DNA damage

DNA Damage Responses following Exposure to Modulated Radiation Fields

During the delivery of advanced radiotherapy treatment techniques modulated beams are utilised to increase dose conformity across the target volume. Recent investigations have highlighted differential cellular responses to modulated radiation fields particularly in areas outside the primary treatment field that cannot be accounted for by scattered dose alone. In the present study, we determined...

Cerebral angiography using gadolinium as an alternative contrast medium in a patient with severe allergy to iodinated contrast medium.

We report cerebral digital subtraction angiography (DSA) using Gadolinium in a patient allergic to iodinated contrast media. A 77-year-old woman was admitted to our hospital for surgical resection of a brain tumor. Although a DSA was requested as a preoperative examination, the patient had a history of allergic reaction to non-ionic iodinated contrast medium. Therefore, DSA was performed using ...

Does Hze Radiation-induced Dna Damage Differ from Low-energy High Let Radiation Damage?

METHODS We have used 1 GeV/u and 600 MeV/u iron ions at NSRL, 300 kVp X-rays and 25 MeV/u nitrogen ions from the 88” cyclotron at Lawrence Berkeley National Laboratory. For measurements of DNA double-strand breaks we are using pulsed-field gel electrophoresis (PFGE) with a dual label technique that includes control samples in each lane and the use of the most sensitive part of the FAR vs dose c...